Publiziertes

Originalarbeiten

 

  • Mellert K, Lechner S, Lüdeke M, Lamla M, Möller P, Kemkemer R, Scheffzek K, Kaufmann D. Restoring functional neurofibromin by protein transduction. Sci Rep. 2018 Apr 8;8(1):6171.
  • Greiner AM, Sales A, Chen H, Biela SA, Kaufmann D, Kemkemer R. Nano- and microstructured materials for in vitro studies of the physiology of vascular cells. Beilstein J Nanotechnol. 2016 Nov 8;7:1620-1641.
  • Kilian HG, Bartkowiak D, Kazda M, Kaufmann D. Modelling the growth of plants with a uniform growth logistics. J Theor Biol. 2014 May 21;349:57-65.
  • Larribere L, Wu H, Novak D, Galach M, Bernhardt M, Orouji E, Weina K, Knappe N, Sachpekidis C, Umansky L, Beckhove P, Umansky V, De Schepper S, Kaufmann D,Ballotti R, Bertolotto C, Utikal J. NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model. Pigment Cell Melanoma Res. 2015 Jul;28(4):407-16.
  • Klingler J, Kaufmann D. Polypropylenimine generation four: a suitable vector for targeted gene alteration in vitro. J Drug Target. 2012 Jun;20(5):474-80.
  • Kaufmann D, Hoesch J, Su Y, Deeg L, Mellert K, Spatz JP, Kemkemer R. Partial Blindness to Submicron Topography in NF1 Haploinsufficient Cultured Fibroblasts Indicates a New Function of Neurofibromin in Regulation of Mechanosensoric. Mol Syndromol. 2012 Oct;3(4):169-79.
  • Uhl M, Mellert K, Striegl B, Deibler M, Lamla M, Spatz JP, Kemkemer R, Kaufmann D (2011) Cyclic stretch increases splicing noise rate in cultured human fibroblasts. BMC Res Notes, 31;4:470.
  • Mellert K, Uhl M, Högel J, Lamla M, Kemkemer R, Kaufmann D (2011) Aberrant single exon skipping is not altered by age in exons of NF1, RABAC1, AATF or PCGF2 in human blood cells and fibroblasts. Genes; 2(3), 562-577
  • Zobor D, Kaufmann DH, Weckerle P, Sauer A, Wissinger B, Wilhelm H, Kohl S (2011) Cone-rod dystrophy associated with amelogenesis imperfecta in a child with neurofibromatosis type 1. Ophthalmic Genet; Jul 5.
  • Kaufmann D, Su Y, Biela S, Jungbauer S, Spatz JP, Kemkemer R (2011) Soft lithography detects partial mechano-sensoric blindness to micrometre topography in cultured aged and diseased cells. IJMR; 102(7): 896-902.
  • Zahl JT, Louban I, Jungbauer S, Bissinger M, Kaufmann D, Kemkemer R, Spatz JP (2011) Age-dependent changes in micro-scale stiffness and mechano-responses of cells. Small; 23;7(10):1480-1487
  • Welti S, Kühn S, D’Angelo I, Brügger B, Kaufmann D, Scheffzek (2011) Structural and Biochemical Consequences of NF1 Associated Non-Truncating Mutations in the Sec14-PH Module of Neurofibromin. Hum Mutat; 32(2):191-197
  • Harder A, Titze S, Herbst L, Harder T, Guse K, Tinschert S, Kaufmann D, Rosenbaum T, Mautner VF, Windt E, Wahlländer-Danek U, Wimmer K, Mundlos S, Peters H (2010) Monozygotic twins with neurofibromatosis type 1 (NF1) display differences in methylation of NF1 gene promoter elements, 5′ untranslated region, exon and intron 1. Twin Res Hum Genet; 13(6):582-594
  • Lamla M, Seliger H, Kaufmann D (2010) Differences in uptake of PNAs modified by COX VIII presequence peptide or by triphenylphoshonium cation into mitochondria of tumour cells. Drug Deliv; 17(4):263-271
  • Kilian HG, Kazda M, Kaufmann D, Kemkemer R, Bartkowiak D (2010) Symmetries of the Structure-bounded Growth Process in Plant populations. Cell Biochem Biophys; 57(2-3):87-100
  • Bartelt-Kirbach B, Wuepping M, Dodrimont-Lattke M, Kaufmann D (2009) Expression analysis of genes lying in the NF1 microdeletion interval points to four candidate modifiers for neurofibroma formation. Neurogenetics; 10(1):79-85
  • Wuepping M, Kenner O, Hegele H, Schwandt S, Kaufmann D (2009) Higher efficiency of TA-clamp modified single stranded oligonucleotides in targeted nucleotide sequence correction is not correlated to a lower intracellular degradation. Hum Gene Ther; 20(3):283-287
  • Kilian HG, Bartkowiak D, Kaufmann D, Kemkemer R (2008) The general growth logistics of cell populations. Cell Biochem Biophys; 51(2-3):51-66
  • Hegele H, Wuepping M, Ref C, Kenner O, Kaufmann D (2008) Simultaneous targeted exchange of two nucleotides by single-stranded oligonucleotides clusters within a region of about fourteen nucleotides. BMC Mol Biol; 28;9(1):14
  • Hanemann CO, Diebold R, Kaufmann D (2007) Role of NF2 haploinsufficiency in NF2-associated polyneuropathy. Brain Pathol; 17(4):371-376
  • Detjen AK, Tinschert S, Kaufmann D, Algermissen B, Nurnberg P, Schuelke M (2007) Analysis of mitochondrial DNA in discordant monozygotic twins with neurofibromatosis type 1. Twin Res Hum Genet;10(3):486-495
  • Kemkemer R, Jungbauer S, Kaufmann D, Gruler H (2006) Cell orientation by a microgrooved substrate can be predicted by automatic control theory. Biophys J; 90(12):4701-4711
  • Kilian HG, Gruler H, Bartkowiak D, Kaufmann D (2005) Stationary cell size distributions and mean protein chain length distributions of Archaea, Bacteria and Eukaryotes described with an increment model in terms of irreversible thermodynamics. Eur Phys J E Soft Matter; 17(3):307-325
  • Kemkemer R, Estrada GG, Kaufmann D, Ulrich D, Gruler, H (2005) Feature extraction of non-stained melanocyte cells. Image Processing, 3, 605-688
  • Hanemann CO, Kaempchen KE, Kaufmann D, Krause BJ (2005) Fludeoxyglucose F 18 positron emission tomography and computed tomography of a giant retroperitoneal schwannoma occurring in a patient with neurofibromatosis type 2. Arch Neurol; 62(4):674-685
  • Diebold R, Bartelt-Kirbach B, Evans DG, Kaufmann D, Hanemann CO (2005) Sensitive detection of deletions of one or more exons in the neurofibromatosis type 2 (NF2) gene by multiplexed gene dosage polymerase chain reaction. J Mol Diagn; 7(1):97-104
  • Kenner O, Lutomska A, Speit G, Vogel W, Kaufmann D (2004) Concurrent targeted exchange of three bases in mammalian hprt by oligonucleotides. Biochem Biophys Res Commun; 321(4):1017-1023
  • Kaufmann D, Kenner O, Nurnberg P, Vogel W, Bartelt B. (2004) In NF1, CFTR, PER3, CARS and SYT7, alternatively included exons show higher conservation of surrounding intron sequences than constitutive exons. Eur J Hum Genet; 12(2):139-149
  • Jungbauer S, Kemkemer R, Gruler H, Kaufmann D, Spatz JP (2004) Cell shape normalization, dendrite orientation, and melanin production of normal and genetically altered (haploinsufficient NF1) melanocytes by microstructured interactions. Chem Phys Chem; 5:85-92
  • Kaufmann D (2004) Molekulargenetische Untersuchungen zur Neurofibromatose 1. Habillitations-Arbeit, Venia legendi für Molekulare Humangenetik
  • Kemkemer R, Csete M, Schrank S, Kaufmann D, Spatz J (2002) The determination of the morphology of melanocytes by laser-generated periodic surface structures. Materials Science and Engineering; C 1064, 1-4  
  • Kemkemer R, Schrank S, Vogel W, Gruler H, Kaufmann D (2002) In­creased noise as an effect of haploinsufficiency of the tumor-suppressor gene neurofibromatosis type 1 in vitro. Proc Natl Acad Sci USA; 99(21):13783-13788
  • Kaufmann D, Leistner W, Kruse P, Kenner O, Hoffmeyer S, Hein C, Vo­gel W, Messiaen L, Bartelt B (2002) Aberrant splicing in several human tumors in the tumor suppressor genes neurofibromatosis type 1, neurofi­bromatosis type 2, and tuberous sclerosis 2. Cancer Res; 62(5):1503-1509
  • Kenner O, Kneisel A, Klingler J, Bartelt B, Speit G, Vogel W, Kaufmann D (2002) Targeted gene correction of hprt mutations by 45 base single stranded oligonucleotides. Biochem Biophys Res Comm; 299(5):787-792
  • Kaufmann D, Müller R, Kenner O, Leistner W, Hein C, Vogel W, Bartelt B (2002) The N-terminal splice product NF1-10a-2 of the NF1 gene codes for a transmembrane segment. Biochem Biophys Res Commun; 294(2):496-503
  • Schultz ES, Kaufmann D, Tinschert S, Schell H, von den Driesch P, Schuler G (2002) Segmental neurofibromatosis. Dermatology; 204(4):296-297
  • Kaufmann D, Müller R, Bartelt B, Wolf M, Kunzi-Rapp K, Hanemann CO, Fahsold R, Hein C, Vogel W, Assum G (2001) Spinal neurofibroma­tosis without cafe-au-lait macules in two families with null mutations of the NF1 gene. Am J Hum Genet; 69(6):1395-1400
  • Kaufmann D, Tinschert S, Algermissen B (2001) Is the distribution of der­mal neurofibromas in neurofibromatosis type 1 (NF1) related to the pattern of the skin surface temperature? Eur J Dermatol; 11(6):521-526
  • Fahsold R, Hoffmeyer S, Mischung C, Gille C, Ehlers C, Kücükceylan N, Ab­del-Nour M, Gewies A, Peters H, Kaufmann D, Buske A, Tinschert S, Nürnberg P (2000) Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain up­stream of the GAP-related domain. Am J Hum Genet; 66(3):790-818
  • Tinschert S, Naumann I, Stegmann E, Buske A, Kaufmann D, Thiel G, Jenne DE (2000) Segmental neurofibromatosis is caused by somatic muta­tion of the neurofibromatosis type 1 (NF1) gene. Eur J Hum Genet; 8(6):455-459
  • Kemkemer R, Kling D, Kaufmann D, Gruhler H (2000) Elastic properties of nematoid arrangements firmed by amoeboid cells. Eur Phys J E; 215-225
  • Kemkemer R, Teichgräber V, Schrank-Kaufmann S, Kaufmann D, Gruler H (2000) Nematic order-disorder state transition in a liquid crystal analogue formed by oriented and migrating amoeboid cells. Eur Phys J E 3; 101-110
  • Kaufmann D, Bartelt B, Hoffmeyer S, Müller R (1999) Posttranslational regu­lation of neurofibromin content in melanocytes of neurofibromatosis type 1 patients. Arch Dermatol Res; 291(6):312-317
  • Kaufmann D, Junge I, Bartelt B, Lattke H, Müller R (1999) On the ly­sosomal degradation of neurofibromin and its phosphorylation in cultured melanocytes. Biol Chem; 380(9):1071-1078
  • Kaufmann D, Gruener S, Braun F, Stark M, Griesser J, Hoffmeyer S, Bartelt B (1999) EVI2B, a gene lying in an intron of the neurofibromatosis type 1 (NF1) gene, is as the NF1 gene involved in differentiation of melano­cytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas. DNA Cell Biol; 18(5):345-356
  • Klose A, Robinson N, Gewies A, Kluwe L, Kaufmann D, Buske A, Tin­schert S. Peters H (1998) Two novel mutations in exons 19a and 20 and a BsaBI [correction of BsaI] polymorphism in a newly characterized intron of the neurofibromatosis type 1 gene. Hum Genet; 102(3):367-371
  • Klose A, Ahmadian MR, Schuelke M, Scheffzek K, Hoffmeyer S, Ge­wies A, Schmitz F, Kaufmann D, Peters H, Wittinghofer A, Nürnberg P (1998) Se­lective disactivation of neurofibromin GAP activity in neurofibro­matosis type 1. Hum Mol Genet; 7(8):1261-1268
  • Hoffmeyer S, Nürnberg P, Ritter H, Fahsold R, Leistner W, Kaufmann D, Krone W (1998) Nearby stop codons in exons of the neurofibromatosis type 1 gene are disparate splice effectors. Am J Hum Genet; 62(2):269-277
  • Krone W, Hoffmeyer S, Griesser H, Kaufmann D, Stark M, Eisenbarth I, Assum G, Kehrer-Sawatzki H (1998) Studies on Neurofibromatosis Type 1. In: J.R. Singh, K. Sperling, Neitzel H: Progress in Human Genetics; Guru Nanak University, Amritsar, India
  • Eisenbarth I, Assum G, Kaufmann D, Krone W (1997) Evidence for the pres­ence of the second allele of the neurofibromatosis type 1 gene in melanocytes derived from cafe au lait macules of NF1 patients. Biochem Biophys Res Commun; 237(1):38-141
  • Griesser J, Kaufmann D, Maier B, Mailhammer R, Kuehl P, Krone W (1997) Post-transcriptional regulation of neurofibromin level in cultured hu­man melanocytes in response to growth factors. J Invest Dermatol; 108(3):275-280
  • Goebeler M, Kaufmann D, Brocker EB, Klein CE (1996) Migration of highly aggressive melanoma cells on hyaluronic acid is associated with functional changes, increased turnover and shedding of CD44 receptors. J Cell Sci; 109(Pt 7):1957-1964
  • Hoffmeyer S, Assum G, Griesser J, Kaufmann D, Nürnberg P, Krone W (1995) On unequal allelic expression of the neurofibromin gene in neuro­fi­bromatosis type 1. Hum Mol Genet; 4(8):1267-1272
  • Griesser J, Kaufmann D, Eisenbarth I, Bäuerle C, Krone W (1995) Ras-GTP regulation is not altered in cultured melanocytes with reduced levels of neurofibromin derived from patients with neurofibromatosis 1 (NF1). Biol Chem Hoppe Seyler; 376(2):91-101
  • Eisenbarth I, Hoffmeyer S, Kaufmann D, Assum G, Krone W (1995) Analy­sis of an alternatively spliced exon of the neurofibromatosis type 1 gene in cultured melanocytes from patients with neurofibromatosis 1. Arch Derma­tol Res; 287(5): 413-416
  • Böddrich A, Griesser J, Horn D, Kaufmann D, Krone W, Nürnberg P (1995) Reduced neurofibromin content but normal GAP activity in a patient with neurofibromatosis type 1 caused by a five base pair duplication in exon 12b of the NF1 gene. Biochem Biophys Res Commun; 214(3):895-904
  • Robinson PN, Böddrich A, Peters H, Tinschert S, Buske A, Kaufmann D, Nürnberg P (1995) Two recurrent nonsense mutations and a 4 bp dele­tion in a quasi-symmetric element in exon 37 of the NF1 gene. Hum Genet; 96(1):95-98
  • Mautner VF, Lindenau M, Kaufmann D (1995) Klinik und Genetik der Neurofibromatosen: Neurofibromatose ist mehr als M. Recklinghausen. Deutsches Ärzteblatt; 92:1758-1764
  • Hoffmeyer S, Assum G, Kaufmann D, Schwenk K, Krone W (1994) A dele­tion in the 5′-region of the neurofibromatosis type 1 (NF1) gene. Hum Genet; 94(1):97-100
  • Hoffmeyer S, Assum G, Kaufmann D, Krone W (1994) Unequal expres­sion of NF1 alleles. Correspondence. Nat Genet; 6(4):331
  • Kaufmann D, Eisenbarth I, Wiandt S, Veser J (1993) Cultured epidermal melanocytes from patients with Neurofibromatosis 1 (M. Recklinghausen): a cell culture model for Neurofibromatosis 1. In: A. Bernd, J. Bereiter-Hahn, F. Hevert, H. Holzmann: Cell and Tissue Culture Models in Dermatological Research; Springer 1993: 148-154
  • Stark M, Assum G, Kaufmann D, Kehrer H, Krone W (1992) Analysis of seg­regation and expression of an identified mutation at the neurofibromato­sis type 1 locus. Hum Genet; 90(4):356-359
  • Kaufmann D, Wiandt S, Veser J, Krone W (1991) Increased melanogene­sis in cultured epidermal melanocytes from patients with neurofibromatosis 1 (NF 1). Hum Genet; 87(2):144-150
  • Kaufmann D, Krone W, Hochsattel R, Martin R (1989) A cell culture study on melanocytes from patients with neurofibromatosis-1. Arch Dermatol Res; 281(7):510-513
  • Kaufmann D (1990) Microinjektion in Zellen in Suspension, Universitätsklinik Mainz, Medizinische Promotionsarbeit, PD Dr. G. Brunner, Dr. med.
  • Kaufmann D (1975) Stadtplanung und der Versuch Heimat zu erhalten. Diplomarbeit, Fakultät für Architektur der RWTH Aachen, Prof. Fehl, Adalbert Ewers, Dipl. Ing
  • Kaufmann D (1973) Kollektive Konsumption und reproduktive Konflikte. Architektur-Vertiefungsarbeit, Lehrstuhl Planungstheorie, Prof. Fehl, Adalbert Ewers, RWTH Aachen
  • Übersichtsarbeiten
  • Dieter Kaufmann (Editor) (2008): Neurofibromatoses, in Monographs in Human Genetics, Vol. 16, KARGER
  • Ralf Kemkemer, Hans Gruler, Dieter Kaufmann, Joachim P Spatz (2004): Cell shape normalization of normal haploinsufficient NF1-melanocytes by micro-structures substrate interaction. In: Function and regulation of cellular systems, Experiments and models. p185-197. Editor: Andreas Deutsch, Jonathan Howard, Martin Falcke, Walter Zimmermann. Birkhäus

Originalarbeiten Dieter Kaufmann